S05-01. Polycomb repressive complexes are required to maintain compact chromatin structure at Hox loci
نویسندگان
چکیده
S05-01 Polycomb repressive complexes are required to maintain compact chromatin structure at Hox loci Ragnhild Eskeland, Duncan Sproul, Graeme Grimes, Shelagh Boyle, Martin Lieb, Clemence Kress, Nick Gilbert, Helle F. Jorgensen, Amanda G. Fisher, Arthur I. Skoultchi, Anton Wutz, Wendy A. Bickmore 1 University of Edinburgh, Edinburgh, United Kingdom 2 Research Institute of Molecular Pathology, Vienna, Austria 3 MRC Clinical Sciences Centre, London, United Kingdom 4 Albert Einstein College of Medicine, Bronx, United States
منابع مشابه
S05-03. Epigenetic control of hox genes collinear activation during vertebrate development
S05-01 Polycomb repressive complexes are required to maintain compact chromatin structure at Hox loci Ragnhild Eskeland, Duncan Sproul, Graeme Grimes, Shelagh Boyle, Martin Lieb, Clemence Kress, Nick Gilbert, Helle F. Jorgensen, Amanda G. Fisher, Arthur I. Skoultchi, Anton Wutz, Wendy A. Bickmore 1 University of Edinburgh, Edinburgh, United Kingdom 2 Research Institute of Molecular Pathology, V...
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S05-01 Polycomb repressive complexes are required to maintain compact chromatin structure at Hox loci Ragnhild Eskeland, Duncan Sproul, Graeme Grimes, Shelagh Boyle, Martin Lieb, Clemence Kress, Nick Gilbert, Helle F. Jorgensen, Amanda G. Fisher, Arthur I. Skoultchi, Anton Wutz, Wendy A. Bickmore 1 University of Edinburgh, Edinburgh, United Kingdom 2 Research Institute of Molecular Pathology, V...
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Mechanisms controlling higher-order chromatin structure or chromatin compaction and linking this to gene regulation are poorly understood. Previously, we had shown that the PRC1 Polycomb repressive complex is required to maintain a compact chromatin state at Polycomb target loci in embryonic stem cells (ESCs) of the mouse and that this activity, together with the ability to repress target gene ...
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How polycomb group proteins repress gene expression in vivo is not known. While histone-modifying activities of the polycomb repressive complexes (PRCs) have been studied extensively, in vitro data have suggested a direct activity of the PRC1 complex in compacting chromatin. Here, we investigate higher-order chromatin compaction of polycomb targets in vivo. We show that PRCs are required to mai...
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Two distinct Polycomb complexes, PRC1 and PRC2, collaborate to maintain epigenetic repression of key developmental loci in embryonic stem cells (ESCs). PRC1 and PRC2 have histone modifying activities, catalyzing mono-ubiquitination of histone H2A (H2AK119u1) and trimethylation of H3 lysine 27 (H3K27me3), respectively. Compared to H3K27me3, localization and the role of H2AK119u1 are not fully un...
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ورودعنوان ژورنال:
- Mechanisms of Development
دوره 126 شماره
صفحات -
تاریخ انتشار 2009